Parkinson’s disease

James Parkinson born in 1755 and died in 1824 in London was an English physician, geologist, paleontologist and political activist. In 1817, he discovered the disease known as “agitating paralysis”. Jean Martin Charcot, an eminent 19th century neurologist, named it “Parkinson’s disease”.

The effects of CBD oil in Parkinson’s disease

There are currently about 10 million people in the world suffering from this disease, including 15,000 in Switzerland. In the majority of cases, it appears in people over 60 years old. But rare exceptions have demonstrated the possibility of contracting this disease early. 5-10% of those diagnosed are under the age of 40 and 20% are under the age of 50. It should be noted that this pathology affects more men than women. It is the second most common neurodegenerative disease after Alzheimer’s and the second most common cause of motor disability after stroke. The patient’s quality of life diminishes year after year, his autonomy decreases and his pain is omnipresent. But it is common to see the patient looking for paramedical solutions to improve their comfort.

Scientific studies have demonstrated the effectiveness of CBD Parkinson in relieving the symptoms of the disease. We will start, therefore, by defining Parkinson’s disease and then we will see the effects of cannabidiol on the patient. We will then evoke the CBD Parkinson testimony of a woman on her mother who has been suffering from the disease for 10 years. Then, we will finish by presenting two scientific studies on the impact of CBD in Parkinson’s disease.

What is Parkinson’s disease?

Parkinson’s disease is a neurodegenerative disorder of the central nervous system. The neurons, responsible for the production of dopamine, are gradually destroyed. This destruction will, therefore, cause motor disorders such as bradykinesia (slowing down, delaying movements). But also rigidity and tremors. Unfortunately, dopaminergic neurons are not the only ones to die. Other neurons are responsible for vegetative disorders (automatic functions of digestion, circulation, breathing, …). Sleep problems, psychological imbalances and pain also appear. Automatic gestures are, therefore, dysfunctional. Hallucinations or delusions may occur during the illness, which may also be caused by the medication. A loss of facial expression can mislead others about the patient’s emotions.

Warning signs

Early warning signs can be observed at the beginning of the disease. Fatigue, depression, pain in the joints or spine are some of the indicators. But they are not enough to diagnose this one. Micrographia (small, tight writing) and loss of arm swing are two important signs.

It is a progressive disease, the patient’s health problems keep increasing over time. There is no cure for this condition. However, drug treatments can reduce or even eliminate the symptoms. Levodopa (L-Dopa) is a dopamine precursor used in medicine for Parkinson’s disease. Other medications also complement the treatment. It should be noted that significant side effects may occur while taking the medication. Depression, anxiety, hallucinations or impulse control disorders (gambling, compulsive buying, etc.) may occur. Apathy (lack of initiative, indifference, …) can also occur.

The causes of the disease are still unknown but two hypotheses are nevertheless retained, genetics and the environment. Long-term exposure to chemicals (pesticides, solvents) is a possible environmental trigger for the disease. It is an extremely difficult condition to treat. But there are products like CBD oil that can reduce the symptoms of Parkinson’s disease.

CBD Oil and Parkinson’s Disease

At this time, scientists have difficulty explaining how the antiparkinsonian effects of CBD occur. Cannabidiol has anti-inflammatory and neuroprotective properties. The destruction of neurons in Parkinson’s disease causes inflammation in the brain. CBD will, therefore, protect the system by curbing inflammation, slowing the neurodegenerative process.

The endocannabinoid system of the human being allows the homeostasis of the body by means of receptors positioned in the whole body. It will regulate the body functions. As a result, CBD can relieve depression, sleep disorders, psychosis and motor problems. It can, in fact, reduce tremors with the appropriate dosage. In addition, it would promote the production of dopamine, an important property in the treatment of Parkinson’s disease. The dosage of cannabidiol should be used with caution. It is important to start with the lowest dose and then adjust it according to the patient’s needs. In addition, several clinical studies have demonstrated the effectiveness of this molecule.

Scientific studies on the effect of CBD oil in Parkinson’s disease

1st study : Cannabidiol for the treatment of psychosis in Parkinson’s disease

It concerns research on the effects of CBD in the treatment of psychosis in Parkinson’s disease. 4 men and 2 women with the disease and psychotic disorders for three months are selected. They are, therefore, given readjustable doses of CBD (1st dose of 150 mg/day) for 4 weeks. The results are very encouraging, with a significant reduction in symptoms during the clinical trials. This is a real hope for medicine and the patient.

Published in Sage Journals in September 2008 by A. W. Zuardi, J. A. S. Crippa, J. E. C. Hallak, JP. Pinto, M. H. N. Chagas, G. G. R. Rodrigues, V. Tumas (Université de São Paulo, Brésil) and SM. Dursun (University of Alberta, Canada).

2nd study: Effects of cannabidiol in the treatment of patients with Parkinson’s disease

21 out of 119 people are selected for clinical trials on the effects of CBD in Parkinson’s disease. They were divided into three groups of 7 people. For 6 weeks, they were treated with placebo, 75 mg CBD/day or 300 mg/day. Scientists have noted an improvement in the quality of life of patients as well as neuroprotective properties.

Published in the magazine Sage Journals in September 2014 by M. H. N. Chagas, A. W. Zuardi, V. Tumas, M. A. Pena-Pereira, E T. Sobreira, M. M . Bergamaschi, A. C. Dos Santo, J. E. C. Hallak, J. A. S. Crippa (Université de São Paulo, Brazil) and A. L. Teixeira (Federal University of Minas Gerais, Brazil).

CBD Parkinson Testimonial:

The daughter of a person with Parkinson’s disease

His mother developed Parkinson’s disease 10 years ago. His treatment was effective for the first few years and then his condition deteriorated. As the medications were no longer as effective as they had been in the beginning, uncontrollable outbursts of anger appeared. CBD has helped her mother find some serenity and her father find more peace. Especially since they found no side effects. As a result, her parents have seen their quality of life improve.

In conclusion

Parkinson’s disease is a neurodegenerative disease that, unfortunately, still has no cure at the present time. The doctor suggests treatments to reduce the symptoms. The quality of life gradually deteriorates, leaving little room for the patient’s autonomy. But in recent years, scientists have discovered therapeutic properties of CBD in people with this condition.

Studies have reported a decrease in motor and non-motor signs after cannabidiol administration. The testimony of a family member of a Parkinson’s patient confirms the effectiveness of CBD in reducing certain symptoms. It should be noted that CBD should not replace the treatment initially prescribed by the neurologist. It comes, therefore, only as a complement.

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